Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate
Drug ID BADD_D01431
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage Methylphenidate is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years of age and older and for the treatment of narcolepsy.
Marketing Status approved; investigational
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D04999
MeSH ID D008774
PubChem ID 4158
TTD Drug ID D02PPN
NDC Product Code 0781-2363; 0378-8263; 0574-2420; 0406-7654; 70165-200; 0378-8261; 68968-5552; 68968-5555; 70165-100; 0781-2362; 0781-2364; 0378-8262; 0574-2410; 0574-2430; 0574-2415; 68968-5553; 70165-300; 68968-5554; 0781-2361; 0378-8260
UNII 207ZZ9QZ49
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 113-45-1
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia17.02.07.003; 07.14.03.0010.001040%
Dyskinesia17.01.02.0060.000880%
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.001024%
Dyspnoea02.11.05.003; 22.02.01.004--
Dystonia17.01.03.0010.000386%Not Available
Ear disorder04.03.01.001--Not Available
Ear infection04.03.01.006; 11.01.05.001--Not Available
Ear pain04.03.01.003--
Ear swelling04.03.01.0140.000041%Not Available
Eating disorder19.09.01.008; 14.03.01.0080.000201%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eczema23.03.04.0060.000111%
Emotional disorder19.04.02.0050.001353%Not Available
Emotional poverty19.04.02.0150.000090%Not Available
Enuresis20.02.02.003; 19.07.04.0010.000140%Not Available
Epilepsy17.12.03.0020.000370%Not Available
Epiphyses premature fusion05.05.03.002; 15.02.02.0010.000041%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Erection increased19.08.04.002; 21.03.01.0040.000160%Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme10.01.03.015; 23.03.01.003--
Erythromelalgia24.03.01.001; 23.06.05.0020.000041%Not Available
Euphoric mood19.04.02.0060.000222%
Exophthalmos06.09.04.001; 05.02.02.0020.000041%Not Available
Exostosis15.02.04.0050.000041%
Extrasystoles02.03.02.003--Not Available
Eye discharge06.04.05.001--Not Available
Eye disorder06.08.03.0010.000312%Not Available
The 6th Page    First    Pre   6 7 8 9 10    Next   Last    Total 23 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene