Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate
Drug ID BADD_D01431
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage Methylphenidate is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years of age and older and for the treatment of narcolepsy.
Marketing Status approved; investigational
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D04999
MeSH ID D008774
PubChem ID 4158
TTD Drug ID D02PPN
NDC Product Code 0781-2363; 0378-8263; 0574-2420; 0406-7654; 70165-200; 0378-8261; 68968-5552; 68968-5555; 70165-100; 0781-2362; 0781-2364; 0378-8262; 0574-2410; 0574-2430; 0574-2415; 68968-5553; 70165-300; 68968-5554; 0781-2361; 0378-8260
UNII 207ZZ9QZ49
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 113-45-1
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Apnoea22.02.01.0010.000103%
Application site erythema23.03.06.005; 12.07.01.001; 08.02.01.0010.005674%Not Available
Application site irritation12.07.01.003; 08.02.01.0030.003655%Not Available
Application site oedema12.07.01.020; 08.02.01.0200.000210%Not Available
Application site pain08.02.01.004; 12.07.01.0040.001838%Not Available
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.0050.003355%Not Available
Application site rash23.03.13.008; 12.07.01.016; 08.02.01.0160.002117%Not Available
Application site reaction08.02.01.006; 12.07.01.006--Not Available
Application site ulcer12.07.01.007; 08.02.01.007; 23.07.03.0100.000140%Not Available
Arrhythmia02.03.02.0010.000391%Not Available
Arteriospasm coronary12.02.01.031; 24.04.04.005; 02.02.02.0050.000062%Not Available
Arteritis24.12.02.0010.000041%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.002--Not Available
Asthma22.03.01.002; 10.01.03.0100.000325%Not Available
Athetosis17.01.01.004--Not Available
Atrioventricular block first degree02.03.01.0040.000041%
Atrioventricular block second degree02.03.01.0050.000062%
Auricular swelling04.01.01.002--Not Available
Autoimmune hepatitis10.04.09.001; 09.01.07.0190.000090%Not Available
Back pain15.03.04.005--
Benign hepatic neoplasm16.06.01.001; 09.04.01.0010.000041%Not Available
Binge eating19.09.01.0010.000090%Not Available
Bipolar I disorder19.16.01.0020.000041%Not Available
Blindness06.02.10.003; 17.17.01.0030.000123%Not Available
Blindness transient06.02.10.006; 17.17.01.0040.000041%Not Available
Blindness unilateral06.02.10.007; 17.17.01.0160.000062%Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.04.018--
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ADReCS-Target
Drug Name ADR Term Target
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