Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Capecitabine
Drug ID BADD_D00349
Description Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Indications and Usage For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.
Marketing Status approved; investigational
ATC Code L01BC06
DrugBank ID DB01101
KEGG ID D01223
MeSH ID D000069287
PubChem ID 60953
TTD Drug ID D00HCQ
NDC Product Code 55111-893; 82920-001; 72205-007; 72485-205; 62331-043; 16714-467; 51407-640; 55111-496; 55111-497; 61269-475; 65162-844; 15308-0714; 54893-0002; 59651-205; 64980-277; 70756-815; 68001-487; 69097-949; 72205-006; 63482-099; 72969-094; 16729-072; 59923-721; 61269-470; 0054-0271; 69539-019; 0093-7473; 64980-276; 0054-0272; 69097-948; 72606-554; 53104-7618; 55512-0015; 0004-1100; 51407-639; 67877-459; 68001-488; 69539-020; 35369-0010; 16729-073; 51407-096; 62756-238; 62756-239; 65162-843; 67877-458; 59651-204; 72485-204; 72606-555; 49452-1713; 68554-0033; 0004-1101; 0093-7474; 51407-095; 60687-149; 0378-2511; 70756-816; 53183-4009; 54245-7014; 65129-1241; 81955-0001; 16714-468; 59923-722
UNII 6804DJ8Z9U
Synonyms Capecitabine | N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine | Xeloda
Chemical Information
Molecular Formula C15H22FN3O6
CAS Registry Number 154361-50-9
SMILES CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Wound secretion12.01.08.007; 08.01.03.035--Not Available
Coronary artery dissection12.02.01.035; 24.02.02.001; 02.02.01.0040.000224%Not Available
Hand and foot syndrome secondary to sickle cell anaemia23.07.04.011; 01.04.02.003--Not Available
Deafness unilateral04.02.01.0110.000112%Not Available
Hypoacusis04.02.01.006--
Onychoclasis23.02.05.0050.001366%Not Available
Performance status decreased08.01.03.0420.000112%Not Available
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.0060.000224%
Weight fluctuation14.03.02.0020.000683%Not Available
Chapped lips07.05.01.0040.000470%Not Available
Rectal discharge07.03.03.0050.000112%Not Available
Neutropenic sepsis01.02.03.007; 11.01.11.006--Not Available
Onychomadesis23.02.05.0060.001533%
Lip blister23.03.01.016; 07.05.01.0070.000873%Not Available
Gingival ulceration07.09.13.0140.000112%Not Available
Sudden cardiac death08.04.01.008; 02.03.04.0160.000280%Not Available
General physical health deterioration08.01.03.0180.003515%Not Available
Oedema due to cardiac disease08.01.07.013; 02.11.01.018--Not Available
Quadriparesis17.01.04.0120.000168%Not Available
Left ventricular dysfunction02.04.02.0110.000560%
Tumour haemorrhage16.32.03.008; 24.07.01.0280.000280%
Balance disorder08.01.03.081; 17.02.02.007--Not Available
Cardiac death08.04.01.007; 02.03.04.0150.000112%Not Available
Anal inflammation07.03.03.0040.000112%
Subileus07.13.01.0040.000280%Not Available
Ventricular hypokinesia02.04.02.0130.000336%Not Available
Lupus-like syndrome15.06.02.004; 10.04.03.003; 23.03.02.0040.000414%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Deep vein thrombosis24.01.02.003--Not Available
Nodular regenerative hyperplasia09.01.04.0040.000112%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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