Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telotristat ethyl
Drug ID BADD_D02503
Description Telotristat only approved oral therapy for carcinoid syndrome diarrhea. Telotristat was approved by the FDA in March, 2017 as Xermelo.
Indications and Usage As a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome.
Marketing Status Not Available
ATC Code A16AX15
DrugBank ID DB12095
KEGG ID D09974
MeSH ID C000621725
PubChem ID 25181577
TTD Drug ID D0RE6T
NDC Product Code 70183-125; 11014-0462; 70720-125
Synonyms telotristat ethyl | Xermelo | LX1032
Chemical Information
Molecular Formula C27H26ClF3N6O3
CAS Registry Number 1033805-22-9
SMILES CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F) F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Stress19.06.02.004-Not Available
Thrombocytopenia01.08.01.002-Not Available
Tricuspid valve incompetence02.07.05.001-Not Available
Viral infection11.05.04.001-Not Available
Vomiting07.01.07.003-
Weight decreased13.15.01.005-
White blood cell count decreased13.01.06.012-
White blood cell count increased13.01.06.013-Not Available
Peripheral swelling08.01.03.053; 02.05.04.015-Not Available
Suprapubic pain08.01.08.017-Not Available
Malignant neoplasm progression16.16.01.005-Not Available
Platelet count increased13.01.04.002-Not Available
Red cell distribution width increased13.01.05.025-Not Available
Cluster headache17.14.01.003-Not Available
Blood alkaline phosphatase increased13.04.02.004-
Malnutrition14.03.02.004-Not Available
Neoplasm progression16.16.02.005-Not Available
Decreased appetite14.03.01.005; 08.01.09.028-
Disease progression08.01.03.038-
Drug intolerance08.06.01.013-Not Available
Metastasis16.22.01.001-Not Available
Regurgitation07.01.07.004-Not Available
Liver function test increased13.03.01.044-Not Available
Endocarditis staphylococcal11.02.05.011; 02.09.03.005-Not Available
Mean cell haemoglobin decreased13.01.05.005-Not Available
Serum serotonin increased13.09.02.001-Not Available
Blood chromogranin A increased13.10.02.012-Not Available
Paracentesis13.18.01.009-Not Available
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