Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Niraparib
Drug ID BADD_D02486
Description Niraparib is an orally active PARP inhibitor developed by Tesaro to treat ovarian cancer. FDA approval on March 2017.
Indications and Usage Niraparib is indicated for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy
Marketing Status Not Available
ATC Code L01XK02
DrugBank ID DB11793
KEGG ID D10140
MeSH ID C545685
PubChem ID 24958200
TTD Drug ID D00BMF
NDC Product Code 71794-103; 69656-103; 61876-0723
Synonyms niraparib | 2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide | niraparib hydrochloride | Zejula | MK 4827 | MK4827 | MK-4827
Chemical Information
Molecular Formula C19H20N4O
CAS Registry Number 1038915-60-4
SMILES C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Malaise08.01.01.0030.006927%
Mania19.16.02.0020.000799%
Mean cell volume increased13.01.05.0220.000533%Not Available
Memory impairment19.20.01.003; 17.03.02.0030.001598%
Metastases to liver16.22.02.001; 09.04.02.0040.000208%Not Available
Middle insomnia19.02.01.003; 17.15.03.0030.000533%Not Available
Migraine24.03.05.003; 17.14.02.0010.001332%Not Available
Monocyte count increased13.01.06.0090.000799%Not Available
Mood altered19.04.02.0070.000533%Not Available
Mucosal inflammation08.01.06.0020.000533%Not Available
Muscle spasms15.05.03.0040.002931%
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.0070.000533%
Myalgia15.05.02.0010.002931%
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.000486%
Nail discolouration23.02.05.0010.000533%
Nasal congestion22.04.04.0010.002131%
Nasopharyngitis22.07.03.002; 11.01.13.0020.001865%Not Available
Nausea07.01.07.0010.039429%
Nervousness19.06.02.0030.001066%Not Available
Neuralgia17.02.07.0050.000799%
Neuropathy peripheral17.09.03.0030.004795%Not Available
Neutropenia01.02.03.0040.004263%Not Available
Neutrophil count decreased13.01.06.0100.001066%
Night sweats08.01.03.031; 23.02.03.0060.000799%Not Available
Nightmare19.02.03.0030.000533%Not Available
Nocturia20.02.03.0010.000533%Not Available
Odynophagia07.05.03.0010.000139%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.0010.000533%
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