Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Niraparib
Drug ID BADD_D02486
Description Niraparib is an orally active PARP inhibitor developed by Tesaro to treat ovarian cancer. FDA approval on March 2017.
Indications and Usage Niraparib is indicated for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy
Marketing Status Not Available
ATC Code L01XK02
DrugBank ID DB11793
KEGG ID D10140
MeSH ID C545685
PubChem ID 24958200
TTD Drug ID D00BMF
NDC Product Code 71794-103; 69656-103; 61876-0723
Synonyms niraparib | 2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide | niraparib hydrochloride | Zejula | MK 4827 | MK4827 | MK-4827
Chemical Information
Molecular Formula C19H20N4O
CAS Registry Number 1038915-60-4
SMILES C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood sodium decreased13.11.01.0120.001865%Not Available
Blood urea increased13.13.01.0060.001332%Not Available
Bone pain15.02.01.0010.000799%
Breast cancer16.10.01.001; 21.05.01.0030.000533%Not Available
Breast pain21.05.05.0030.000533%
Bronchitis22.07.01.001; 11.01.09.0010.000533%
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.0010.000799%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Colitis07.08.01.0010.000533%
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.0010.019714%
Cough22.02.03.0010.006394%
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.000533%Not Available
Death08.04.01.0010.006463%
Dehydration14.05.05.0010.007193%
Depressed mood19.15.02.0010.000799%Not Available
Depression19.15.01.0010.002664%
Diabetes mellitus14.06.01.001; 05.06.01.0010.000533%Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.0150.000799%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.000799%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.009591%
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.0050.000799%Not Available
Dry mouth07.06.01.0020.005062%
Dry throat22.02.05.004; 07.06.01.0050.000533%Not Available
Dysarthria19.19.03.001; 17.02.08.0010.000533%
Dysgeusia07.14.03.001; 17.02.07.0030.003197%
Dyspepsia07.01.02.0010.002398%
Dysphagia07.01.06.0030.002664%
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