Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fingolimod
Drug ID BADD_D02464
Description Multiple sclerosis or MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects.[A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010.[L12651] Fingolimod is currently being studied for the treatment of COVID-19, the disease caused by infection with the SARS-CoV-2 virus. Phase 2 clinical trials are currently underway and completion is expected in July 2020.[L12654]
Indications and Usage Fingolimod is a sphingosine 1-phosphate receptor modulator indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability.
Marketing Status Not Available
ATC Code L04AA27
DrugBank ID DB08868
KEGG ID D10001
MeSH ID D000068876
PubChem ID 107970
TTD Drug ID D07UHS
NDC Product Code 54893-0026; 65035-201
Synonyms Fingolimod Hydrochloride | 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride | FTY-720 | FTY 720 | FTY720 | Gilenya | Gilenia | Fingolimod
Chemical Information
Molecular Formula C19H33NO2
CAS Registry Number 162359-55-9
SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood bilirubin increased13.03.01.0080.057320%
Blood calcium decreased13.11.01.002--Not Available
Blood calcium increased13.11.01.0030.004053%Not Available
Blood chloride increased13.11.01.0050.001737%Not Available
Blood cholesterol abnormal13.12.01.0090.002316%Not Available
Blood cholesterol decreased13.12.01.0010.002895%Not Available
Blood cholesterol increased13.12.01.0020.070637%
Blood creatine increased13.13.01.001--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine decreased13.13.01.0030.005211%Not Available
Blood creatinine increased13.13.01.004--
Blood glucose abnormal13.02.02.008--Not Available
Blood glucose decreased13.02.02.0010.006369%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood immunoglobulin G decreased13.06.05.0010.005211%Not Available
Blood immunoglobulin G increased13.06.05.0040.002316%Not Available
Blood immunoglobulin M decreased13.06.05.0060.001737%Not Available
Blood iron decreased13.11.01.0060.005211%Not Available
Blood iron increased13.11.01.0070.001158%Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood lactic acid increased13.02.01.015--Not Available
Blood magnesium decreased13.11.01.008--Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood potassium increased13.11.01.011--Not Available
Blood pressure abnormal13.14.03.0010.006369%Not Available
Blood pressure decreased13.14.03.0020.080480%Not Available
Blood pressure diastolic decreased13.14.03.0030.002895%Not Available
Blood pressure diastolic increased13.14.03.0040.005211%Not Available
Blood pressure fluctuation24.06.01.0020.015633%Not Available
Blood pressure increased13.14.03.0050.108850%Not Available
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