Pharmaceutical Information |
Drug Name |
Methylnaltrexone |
Drug ID |
BADD_D02462 |
Description |
Methylnaltrexone is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008. |
Indications and Usage |
Treatment of opioids induced constipation in palliative patients that are inadequately responding to laxative therapy. |
Marketing Status |
Not Available |
ATC Code |
A06AH01 |
DrugBank ID |
DB06800
|
KEGG ID |
D06618
|
MeSH ID |
C032257
|
PubChem ID |
5361918
|
TTD Drug ID |
D03YVO
|
NDC Product Code |
Not Available |
Synonyms |
methylnaltrexone | quaternary ammonium naltrexone | (5alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-17-methyl-4,5-epoxymorphinan-17-ium-6-one | 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinanium-6-one | morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, (5alpha)- | morphinan-17-ium-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-, (5alpha)- | naltrexone methylbromide | N-methylnaltrexone bromide | morphinan-17-ium-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-, bromide, (5alpha,17R)- | naltrexone MB | naltrexone methobromide | methylnaltrexone bromide | methyl-naltrexone hydrobromide | MRZ 2663BR | Relistor | MRZ-2663 | naltrexonium methiodide |
|
Chemical Information |
Molecular Formula |
C21H26NO4+ |
CAS Registry Number |
83387-25-1 |
SMILES |
C[N+]1(CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O)CC6CC6 |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
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ADRs Induced by Drug |
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