Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexmethylphenidate
Drug ID BADD_D02457
Description Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181].
Indications and Usage Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment.
Marketing Status Not Available
ATC Code N06BA11
DrugBank ID DB06701
KEGG ID D07806
MeSH ID D064699
PubChem ID 154101
TTD Drug ID D02QCD
NDC Product Code Not Available
Synonyms Dexmethylphenidate Hydrochloride | Hydrochloride, Dexmethylphenidate | Focalin XR | XR, Focalin | Dexmethylphenidate | Focalin
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 40431-64-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.001200%Not Available
Abdominal pain07.01.05.0020.001600%
Abdominal pain upper07.01.05.0030.004001%
Affective disorder19.04.04.0010.001200%Not Available
Aggression19.05.01.0010.003201%Not Available
Agitation19.06.02.001; 17.02.05.0120.002001%
Amnesia19.20.01.001; 17.03.02.0010.000800%
Anger19.04.02.0010.002001%Not Available
Anxiety19.06.02.0020.004401%
Asthenia08.01.01.001--Not Available
Attention deficit/hyperactivity disorder19.21.04.0010.003201%Not Available
Blindness17.17.01.003; 06.02.02.0010.000800%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000800%Not Available
Chills15.05.03.016; 08.01.09.0010.000800%
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.002401%Not Available
Depressed mood19.15.02.0010.001200%Not Available
Depression19.15.01.0010.002001%
Diarrhoea07.02.01.001--
Discomfort08.01.08.0030.000800%Not Available
Disorientation17.02.05.015; 19.13.01.0020.000800%Not Available
Distractibility19.21.02.0070.000800%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.004801%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.002401%
Dry mouth07.06.01.0020.004001%
Dysphagia07.01.06.0030.003601%
Dyspnoea22.02.01.004; 02.01.03.0020.002001%
Dystonia17.01.03.0010.000800%Not Available
Eating disorder19.09.01.008; 14.03.01.0080.000800%Not Available
Emotional disorder19.04.02.0050.002001%Not Available
Enuresis20.02.02.003; 19.07.04.0010.000800%Not Available
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