Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vilazodone
Drug ID BADD_D02456
Description Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Indications and Usage Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediatrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone.
Marketing Status Not Available
ATC Code N06AX24
DrugBank ID DB06684
KEGG ID D09698
MeSH ID D000069503
PubChem ID 6918314
TTD Drug ID D0X6BV
NDC Product Code Not Available
Synonyms Vilazodone Hydrochloride | Hydrochloride, Vilazodone | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | Vilazodone HCl | HCl, Vilazodone | Viibryd | EMD 68843 | 68843, EMD | EMB-68843 | EMB 68843 | EMB68843 | Vilazodone | 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide
Chemical Information
Molecular Formula C26H27N5O2
CAS Registry Number 163521-12-8
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Speech disorder22.02.05.034; 17.02.08.003; 19.19.02.0020.001485%Not Available
Suicidal ideation19.12.01.0030.046771%
Suicide attempt19.12.01.0040.011878%
Swelling face23.04.01.018; 10.01.05.0180.001485%Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.002970%
Tachycardia02.03.02.007--Not Available
Tic19.11.04.001; 17.02.05.0240.001485%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.002970%
Tongue disorder07.14.01.0020.001485%Not Available
Tremor17.01.06.0020.008166%
Urinary retention20.02.02.0110.002227%
Urticaria23.04.02.001; 10.01.06.0010.003712%
Vaginal haemorrhage24.07.03.005; 21.08.01.0010.001485%
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.0070.004454%
Vomiting07.01.07.003--
Weight increased13.15.01.0060.012621%
Withdrawal syndrome19.07.02.005; 08.06.02.0120.007424%Not Available
Mental status changes19.07.01.0010.001485%Not Available
Energy increased08.01.03.0170.002227%Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Emotional distress19.04.02.008--Not Available
Muscle tightness15.05.03.0070.001485%Not Available
Balance disorder17.02.02.007--Not Available
Dysstasia17.02.02.0120.001485%Not Available
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.0010.003712%
Pruritus generalised23.03.12.0030.002227%Not Available
Musculoskeletal stiffness15.03.01.0050.002970%Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.001485%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.001485%Not Available
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