Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vilazodone
Drug ID BADD_D02456
Description Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Indications and Usage Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediatrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone.
Marketing Status Not Available
ATC Code N06AX24
DrugBank ID DB06684
KEGG ID D09698
MeSH ID D000069503
PubChem ID 6918314
TTD Drug ID D0X6BV
NDC Product Code Not Available
Synonyms Vilazodone Hydrochloride | Hydrochloride, Vilazodone | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | Vilazodone HCl | HCl, Vilazodone | Viibryd | EMD 68843 | 68843, EMD | EMB-68843 | EMB 68843 | EMB68843 | Vilazodone | 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide
Chemical Information
Molecular Formula C26H27N5O2
CAS Registry Number 163521-12-8
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Generalised tonic-clonic seizure17.12.01.0020.004454%Not Available
Glycosylated haemoglobin increased13.02.02.0050.001485%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.002227%Not Available
Hallucination19.10.02.0020.024499%
Hallucination, auditory19.10.02.0030.005939%Not Available
Hallucination, visual19.10.02.0040.002970%Not Available
Hallucinations, mixed19.10.02.0070.002227%Not Available
Headache17.14.01.0010.018560%
Heart rate increased13.14.04.0020.002227%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.008909%
Hypersensitivity10.01.03.0030.005197%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.0230.006682%Not Available
Hypomania19.16.02.0010.001485%Not Available
Hyponatraemia14.05.04.0020.002970%
Increased appetite14.03.01.003; 08.01.09.0270.002227%Not Available
Insomnia19.02.01.002; 17.15.03.0020.023014%
Irritability19.04.02.013; 08.01.03.0110.007424%
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.0040.001485%Not Available
Libido decreased21.03.02.005; 19.08.03.0010.001485%
Loss of consciousness17.02.04.0040.003712%Not Available
Malaise08.01.01.003--
Mania19.16.02.0020.011136%
Memory impairment17.03.02.003; 19.20.01.0030.004454%
Migraine24.03.05.003; 17.14.02.0010.002227%Not Available
Mood swings19.04.03.0010.001485%Not Available
Movement disorder17.01.02.0100.002970%Not Available
Muscle spasms15.05.03.0040.008909%
Muscle twitching15.05.03.0050.005939%Not Available
Nausea07.01.07.0010.033408%
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