Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Crisaborole
Drug ID BADD_D02450
Description Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reducing the signs and symptoms in patients 2 years old and older. It reduces the local inflammation in the skin and prevents further exacerbation of the disease with a good safety profile. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. It is currently under development as topical treatment of psoriasis.
Indications and Usage Intended for the topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older.
Marketing Status Not Available
ATC Code D11AH06
DrugBank ID DB05219
KEGG ID D10873
MeSH ID C543085
PubChem ID 44591583
NDC Product Code 0009-0211; 17337-0546; 69037-0041; 46438-0656; 53296-0124; 55724-211; 69766-043; 16436-0124; 69575-4035; 57572-0715; 58175-0622; 11722-066
Synonyms crisaborole | Eucrisa | AN2728 | AN-2728 | 5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole
Chemical Information
Molecular Formula C14H10BNO3
CAS Registry Number 906673-24-3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acne23.02.01.0010.004393%Not Available
Anaphylactic reaction24.06.03.006;
Blepharitis23.03.04.012; Available
Blister23.03.01.001; Available
Burning sensation17.02.06.001; Available
Crying12.02.11.001;;; Available
Dermatitis23.03.04.0020.004393%Not Available
Dermatitis allergic23.03.04.003; Available
Dermatitis atopic23.03.04.016; Available
Dermatitis contact10.01.01.003;; Available
Dermatitis exfoliative23.03.07.001;
Discomfort08.01.08.0030.001757%Not Available
Drug hypersensitivity10.01.01.0010.034266%Not Available
Dry skin23.03.03.0010.007908%
Erythema23.03.06.0010.036902%Not Available
Erythema of eyelid23.03.06.006; Available
Eye inflammation06.04.05.0020.000879%Not Available
Eye irritation06.04.05.0030.007468%Not Available
Eye pain06.08.03.0020.003514%
Eye swelling06.08.03.0030.006150%Not Available
Eyelid oedema06.04.04.004;; Available
Facial pain08.01.08.0120.008347%
Feeling abnormal08.01.09.014--Not Available
Herpes simplex23.09.03.001; Available
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