Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorcaserin
Drug ID BADD_D02448
Description Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.
Indications and Usage For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Marketing Status Not Available
ATC Code A08AA11
DrugBank ID DB04871
KEGG ID D06613
MeSH ID C506658
PubChem ID 11658860
TTD Drug ID D01JMC
NDC Product Code Not Available
Synonyms lorcaserin | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | Belviq | AR-10A | 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine | APD 356 | APD356 | APD-356
Chemical Information
Molecular Formula C11H14ClN
CAS Registry Number 616202-92-7
SMILES CC1CNCCC2=C1C=C(C=C2)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000568%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.001277%Not Available
Aggression19.05.01.0010.000284%Not Available
Agitation19.06.02.001; 17.02.05.0120.000568%
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.0010.000568%
Anger19.04.02.0010.000284%Not Available
Anxiety19.06.02.0020.002129%
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.000426%
Back pain15.03.04.0050.001277%
Blood glucose decreased13.02.02.0010.000284%Not Available
Blood glucose increased13.02.02.0020.000426%Not Available
Blood pressure increased13.14.03.0050.001135%Not Available
Blood prolactin increased13.10.03.0020.000284%Not Available
Bradycardia02.03.02.0020.000426%Not Available
Breast enlargement21.05.04.0010.000284%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000284%Not Available
Chest pain08.01.08.002; 22.02.08.003; 02.02.02.0110.000710%Not Available
Chills15.05.03.016; 08.01.09.0010.000851%
Confusional state19.13.01.001; 17.02.03.0050.001845%
Constipation07.02.02.0010.001987%
Cough22.02.03.001--
Crying12.02.11.001; 08.01.03.005; 19.04.02.002; 17.02.05.0130.000284%Not Available
Depression19.15.01.0010.001845%
Diarrhoea07.02.01.001--
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