Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiotropium
Drug ID BADD_D02443
Description Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium].[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Indications and Usage Used in the management of chronic obstructive pulmonary disease (COPD).
Marketing Status Not Available
ATC Code R03BB04
DrugBank ID DB01409
KEGG ID D01929
MeSH ID D000069447
PubChem ID 5487427
TTD Drug ID D0P1WA
NDC Product Code Not Available
Synonyms Tiotropium Bromide | Bromide, Tiotropium | 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide | Tiotropium | Spiriva | BA 679 BR | 679 BR, BA | BR, BA 679 | BA-679 BR | BA679 BR
Chemical Information
Molecular Formula C19H22NO4S2+
CAS Registry Number 186691-13-4
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.001582%
Oesophageal candidiasis11.03.03.008; 07.19.06.0010.000487%Not Available
Oral candidiasis11.03.03.004; 07.05.07.0010.000608%Not Available
Oral discomfort07.05.05.0010.000730%Not Available
Oral pain07.05.03.0020.000608%
Oropharyngeal swelling23.04.01.013; 22.04.05.005; 10.01.05.014; 07.05.04.0020.000243%Not Available
Osteoarthritis15.01.04.001--Not Available
Osteoporosis15.02.03.002; 14.04.04.0020.000852%
Oxygen saturation decreased13.02.01.0040.001217%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain in jaw15.02.01.0030.000365%Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.000365%Not Available
Palpitations02.01.02.003--
Pancreatic carcinoma16.13.10.001; 07.21.09.0020.000063%Not Available
Pancytopenia01.03.03.003--Not Available
Panic attack19.06.04.0010.000487%Not Available
Panic reaction19.06.04.0030.000243%Not Available
Paraesthesia17.02.06.005--
Parosmia17.04.04.002; 22.04.03.0070.000243%Not Available
Pericardial effusion02.06.01.002--
Periodontal disease07.09.05.0060.000243%
Pharyngeal haemorrhage24.07.02.017; 22.04.05.0020.000243%
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.001095%Not Available
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.0040.000487%
Pharyngitis streptococcal22.07.04.001; 11.02.06.0020.000487%Not Available
Pleural effusion22.05.02.002--
Pleurisy22.05.01.0010.000243%Not Available
Pleuritic pain22.02.04.0080.000243%
Pneumonia22.07.01.003; 11.01.09.0030.017888%Not Available
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