Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiotropium
Drug ID BADD_D02443
Description Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium].[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Indications and Usage Used in the management of chronic obstructive pulmonary disease (COPD).
Marketing Status Not Available
ATC Code R03BB04
DrugBank ID DB01409
KEGG ID D01929
MeSH ID D000069447
PubChem ID 5487427
TTD Drug ID D0P1WA
NDC Product Code Not Available
Synonyms Tiotropium Bromide | Bromide, Tiotropium | 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide | Tiotropium | Spiriva | BA 679 BR | 679 BR, BA | BR, BA 679 | BA-679 BR | BA679 BR
Chemical Information
Molecular Formula C19H22NO4S2+
CAS Registry Number 186691-13-4
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Multiple organ dysfunction syndrome08.01.03.057--
Abnormal loss of weight14.03.02.0190.001095%Not Available
Cardiac failure chronic02.05.01.0090.000243%Not Available
Chronic respiratory failure14.01.04.005; 22.02.06.0050.000095%Not Available
Congenital cystic lung03.16.01.004; 22.10.01.0030.000243%Not Available
Foetal malnutrition18.03.01.0040.000608%Not Available
Lung adenocarcinoma22.08.01.007; 16.19.01.0020.000095%Not Available
Metastases to lymph nodes01.09.01.015; 16.22.02.0060.000243%Not Available
Open angle glaucoma06.03.01.0040.000365%Not Available
Pneumonia influenzal22.07.05.008; 11.05.03.0030.000063%Not Available
Respiratory rate increased13.15.01.0040.000243%Not Available
Spinal column stenosis15.10.04.003; 17.10.01.0110.000243%Not Available
Lumbar vertebral fracture15.08.05.007; 12.04.04.0070.000243%Not Available
Perineal fistula21.10.05.0180.000608%Not Available
Infective exacerbation of chronic obstructive airways disease22.03.01.022; 11.01.09.0150.000487%Not Available
Sputum retention22.02.03.0120.000243%Not Available
Lung adenocarcinoma metastatic16.19.01.004; 22.08.01.0100.000063%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000365%Not Available
Disuse syndrome08.01.03.0670.000365%Not Available
Abdominal wall haematoma24.07.02.039; 07.16.05.0050.000608%Not Available
Respiratory tract inflammation22.02.07.0150.000243%Not Available
Inflammatory marker increased13.09.02.0030.000243%Not Available
Pulmonary pain22.02.04.0130.000243%Not Available
Intracranial mass17.11.01.0170.000095%Not Available
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