Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Enoxaparin
Drug ID BADD_D02438
Description Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies.[L31393] Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Indications and Usage For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Marketing Status Not Available
ATC Code B01AB01; B01AB12; C05BA03; S01XA14
DrugBank ID DB01225
KEGG ID D07510
MeSH ID D017984
PubChem ID 772
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Enoxaparin | Enoxaparine | PK-10,169 | PK 10,169 | PK10,169 | PK-10169 | PK 10169 | PK10169 | EMT-967 | EMT 967 | EMT967 | Lovenox | Clexane | EMT-966 | EMT 966 | EMT966
Chemical Information
Molecular Formula C26H42N2O37S5
CAS Registry Number 9005-49-6
SMILES CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C( C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Apnoea22.02.01.0010.001049%
Areflexia17.02.01.0010.000411%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.001574%
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.003673%
Aspartate aminotransferase increased13.03.01.0060.004722%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.005771%
Auricular swelling04.01.01.0020.001049%Not Available
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.0010.002623%Not Available
Blister23.03.01.001; 12.01.06.0020.003673%Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.0040.005247%
Blood lactate dehydrogenase increased13.04.02.0020.002623%
Blood potassium decreased13.11.01.0100.001049%Not Available
Blood pressure decreased13.14.03.0020.000821%Not Available
Blood pressure increased13.14.03.005--Not Available
Bradycardia02.03.02.0020.003673%Not Available
Brain herniation17.11.01.002; 12.01.10.0010.000411%Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.002623%
Bundle branch block right02.03.01.0110.000274%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.002099%Not Available
C-reactive protein increased13.09.01.0070.002623%Not Available
Cardiac arrest02.03.04.0010.002737%
Cardiac failure02.05.01.001--
Cardiac tamponade02.06.01.0010.001574%
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.001095%Not Available
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