Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status approved
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 72865-150; 72865-151; 72865-152; 42291-459; 65862-832; 16714-080; 42291-461; 67877-504; 68180-228; 42543-962; 47335-600; 51407-297; 63629-8765; 63629-8764; 63629-9607; 64380-885; 67877-503; 69097-410; 69097-412; 47335-380; 50268-153; 51407-296; 76282-674; 76282-675; 16729-440; 16729-441; 31722-104; 65162-155; 65162-213; 67877-505; 42291-460; 42543-961; 43598-368; 65162-157; 65862-831; 69097-411; 43598-369; 63629-8763; 63629-9606; 63629-9608; 65862-833; 68180-226; 31722-103; 47335-379; 60687-525; 64380-883; 68180-227; 76282-676; 0904-7067; 31722-105; 43598-367; 64380-884; 16729-442; 42543-963; 51407-295
UNII UAZ6V7728S
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urine abnormality20.02.01.0130.000860%Not Available
Vein disorder24.03.02.0150.000860%Not Available
Venous thrombosis24.01.01.0080.000782%Not Available
Volvulus07.13.01.0120.000391%Not Available
Vomiting07.01.07.0030.485197%
Vomiting projectile07.01.07.0120.001525%Not Available
Musculoskeletal disorder15.03.05.0250.009616%Not Available
Catheter site haemorrhage12.07.02.002; 08.02.02.002; 24.07.01.0030.001994%Not Available
Fluid imbalance14.05.01.0030.001055%Not Available
Calciphylaxis14.04.01.0120.003987%Not Available
Large intestinal haemorrhage24.07.02.026; 07.12.03.0030.000586%
Cardiac flutter02.03.02.0120.000586%Not Available
Epigastric discomfort07.01.02.0040.003323%Not Available
Secretion discharge08.01.03.0190.003323%Not Available
Increased viscosity of bronchial secretion22.12.01.0030.001329%Not Available
Fluid intake reduced14.05.10.0010.001329%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.005316%Not Available
Paraesthesia oral07.05.05.035; 17.02.06.0080.004652%Not Available
Venous occlusion24.04.02.0090.001055%Not Available
Angiopathy24.03.02.0070.001055%Not Available
Adhesion08.01.03.0480.000391%Not Available
Adverse event08.06.01.0100.239315%Not Available
Appetite disorder19.09.01.002; 14.03.01.0040.018060%Not Available
Cardiac disorder02.11.01.0030.018216%Not Available
Diabetic complication14.07.03.002; 05.07.03.0020.000391%Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.006567%Not Available
Spondylitis15.01.09.0020.001173%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.329576%
Renal neoplasm20.01.04.004; 16.08.03.0010.000391%Not Available
Intervertebral disc disorder15.10.01.0030.000391%Not Available
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