Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibandronate
Drug ID BADD_D02426
Description Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805]
Indications and Usage For the treatment and prevention of osteoporosis in postmenopausal women.
Marketing Status Not Available
ATC Code M05BA06
DrugBank ID DB00710
KEGG ID D04486
MeSH ID D000077557
PubChem ID 60852
TTD Drug ID D08SJZ
NDC Product Code Not Available
Synonyms Ibandronic Acid | Ibandronate | 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonate | (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonate | Ibandronate Sodium Anhydrous | Boniva | Bonviva | Ibandronate Sodium | Ibandronic Acid, Sodium Salt, Monohydrate | RPR 102289A | RPR-102289A | RPR102289A | Bondronat | BM 21.0955 | BM 210955 | BM-21.0955 | BM21.0955 | BM-210955 | BM210955
Chemical Information
Molecular Formula C9H23NO7P2
CAS Registry Number 114084-78-5
SMILES CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Treatment failure08.06.01.017--Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.003559%
Atypical femur fracture12.04.01.019; 15.08.03.0190.002847%Not Available
Mouth swelling10.01.05.020; 07.05.04.007; 23.04.01.0200.002135%Not Available
Brain neoplasm malignant16.30.04.002; 17.20.04.0020.000371%Not Available
Exostosis of jaw15.02.04.0330.002135%Not Available
Fear of disease19.06.03.0070.001423%Not Available
Fibula fracture12.04.01.011; 15.08.03.0110.002135%Not Available
Forearm fracture15.08.03.013; 12.04.01.0130.002847%Not Available
Fracture delayed union15.08.01.002; 12.04.02.0150.001423%Not Available
Tibia fracture15.08.03.016; 12.04.01.0160.001423%Not Available
Lower extremity mass15.03.01.0150.002847%Not Available
Fracture displacement15.08.02.013; 12.04.02.0160.001423%Not Available
Low turnover osteopathy20.01.01.010; 15.02.03.016; 14.04.04.0150.002847%Not Available
Quality of life decreased13.18.01.0130.001423%Not Available
Bone density abnormal13.16.01.0050.002135%Not Available
Periprosthetic fracture15.08.02.015; 12.02.13.0030.002135%Not Available
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