Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Radium ra 223 dichloride
Drug ID BADD_D02406
Description Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first approved by the FDA in May 2013 and is currently marketed under the brand name Xofigo, which was formerly called Alpharadin. Xofigo is indicated in patients who have metastatic bone cancer that is symptomatic with no visceral metastases and patients who have prostate cancer that is castration resistant. The FDA label includes a warning that Radium Ra 223 Dichloride should not be used in women who are pregnant or may become pregnant due to the high risk of fetal harm.
Indications and Usage Not Available
Marketing Status Not Available
ATC Code V10XX03
DrugBank ID DB08913
KEGG ID D10398
MeSH ID C581106
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code 50419-208
Synonyms radium Ra 223 dichloride | radium chloride Ra 223 | Xofigo
Chemical Information
Molecular Formula Not Available
CAS Registry Number 444811-40-9
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac failure02.05.01.001-
Cardiac failure acute02.05.01.005-Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cellulitis23.09.01.001; 11.02.01.001-Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003-Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.005-
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Circulatory collapse24.06.02.001-Not Available
Colon cancer16.13.01.001; 07.21.01.001-Not Available
Coma17.02.09.001--Not Available
Compression fracture15.08.02.004; 12.04.02.008-Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001-
Dehydration14.05.05.001-
Delirium19.13.02.001-
Dementia19.20.02.001; 17.03.01.001-Not Available
Depressed level of consciousness17.02.04.002--
Diarrhoea07.02.01.001--
Disseminated intravascular coagulation24.01.01.010; 01.01.02.002-
Dizziness24.06.02.007; 02.01.02.004; 17.02.05.003--
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Electrolyte imbalance14.05.01.002-Not Available
Epistaxis24.07.01.005; 22.04.03.001--
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