Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Radium ra 223 dichloride
Drug ID BADD_D02406
Description Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first approved by the FDA in May 2013 and is currently marketed under the brand name Xofigo, which was formerly called Alpharadin. Xofigo is indicated in patients who have metastatic bone cancer that is symptomatic with no visceral metastases and patients who have prostate cancer that is castration resistant. The FDA label includes a warning that Radium Ra 223 Dichloride should not be used in women who are pregnant or may become pregnant due to the high risk of fetal harm.
Indications and Usage Not Available
Marketing Status Not Available
ATC Code V10XX03
DrugBank ID DB08913
KEGG ID D10398
MeSH ID C581106
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code 50419-208
Synonyms radium Ra 223 dichloride | radium chloride Ra 223 | Xofigo
Chemical Information
Molecular Formula Not Available
CAS Registry Number 444811-40-9
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal faeces07.01.03.001-Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.001-Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute respiratory distress syndrome22.01.03.001-
Acute respiratory failure14.01.04.004; 22.02.06.001-Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.001-
Alanine aminotransferase increased13.03.01.003--
Altered state of consciousness19.07.01.003; 17.02.04.001-Not Available
Anaemia01.03.02.001-
Apathy19.04.04.002-Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Aspiration22.02.07.007-
Asthenia08.01.01.001-Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005-
Bacteraemia11.01.11.001-
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002-
Blood pressure increased13.14.03.005--Not Available
Blood urea increased13.13.01.006-Not Available
Bone pain15.02.01.001-
C-reactive protein increased13.09.01.007-Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.009-Not Available
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