| Drug Name |
Zonisamide |
| Drug ID |
BADD_D02396 |
| Description |
Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate. |
| Indications and Usage |
For use as adjunctive treatment of partial seizures in adults with epilepsy. |
| Marketing Status |
approved; investigational |
| ATC Code |
N03AX15 |
| DrugBank ID |
DB00909
|
| KEGG ID |
D00538
|
| MeSH ID |
D000078305
|
| PubChem ID |
5734
|
| TTD Drug ID |
D09ZIS
|
| NDC Product Code |
76282-228; 13672-001; 60510-611; 65841-125; 70600-003; 59651-380; 63629-3293; 68001-242; 68462-129; 70771-1143; 72578-040; 76282-226; 38217-0040; 59651-378; 35356-143; 59212-681; 63187-897; 70518-3224; 70771-1144; 49452-9000; 76072-1012; 0615-8266; 72578-041; 60687-230; 61919-917; 62756-259; 62756-260; 17511-137; 68554-0009; 29300-430; 63187-583; 69097-861; 71335-0486; 71052-065; 52652-8001; 68001-244; 76282-227; 13672-002; 51927-0109; 51927-4807; 59361-002; 59212-680; 59651-379; 46438-0063; 60510-610; 66039-122; 73309-257; 29300-429; 62756-258; 70771-1142; 51552-1572; 73377-112; 68001-243; 68788-7438; 72578-042; 62756-334; 29300-428; 50268-816; 68462-128; 68462-130; 70518-3180; 71205-727; 71335-0962; 71335-9679; 72189-374; 38779-3045; 66039-929 |
| UNII |
459384H98V
|
| Synonyms |
Zonisamide | 3-Sulfamoylmethyl-1,2-benzisoxazole | 3 Sulfamoylmethyl 1,2 benzisoxazole | AD 810 | AD-810 | AD810 | CI 912 | CI-912 | CI912 | Zonegran | Zonisamide Monosodium |
