Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.[L9821, L15571]
Marketing Status approved
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0781-5667; 60715-1700; 65372-1175; 27241-063; 39822-1077; 43386-088; 0378-1640; 66039-951; 70966-0030; 47781-466; 0049-4190; 55111-099; 58032-2007; 66039-876; 43386-038; 51079-164; 0049-3190; 64980-274; 64980-275; 65862-891; 68462-572; 70594-067; 70710-1247; 60687-273; 0378-1626; 65841-830; 72572-875; 68554-0111; 75945-102; 16714-199; 43547-378; 59762-0936; 63739-008; 65162-913; 65841-831; 0904-6596; 65862-916; 71052-149; 40032-038; 43386-089; 50268-803; 0049-3180; 68083-321; 71288-027; 72578-062; 14501-0014; 52562-001; 27241-062; 43547-377; 51552-1524; 16714-198; 59762-0934; 60687-294; 65219-190; 65862-892; 70771-1413; 72843-441; 0781-5668; 63126-911; 0049-3170; 70436-029; 72578-063; 0781-3416; 0904-7024; 51552-1573; 53296-0081; 64220-140; 65015-801; 73223-005; 51079-165; 63629-8734; 0049-3160; 68462-573; 72266-131; 51407-133; 55150-321; 59762-0935
UNII JFU09I87TR
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mental status changes19.07.01.0010.108619%Not Available
Cardiotoxicity02.11.01.009; 12.03.01.0070.017426%Not Available
Hydrothorax22.05.02.0040.011617%Not Available
Hypoacusis04.02.01.006--
Retinal toxicity12.03.01.036; 06.09.03.0130.026138%Not Available
Brain oedema17.07.02.003; 12.01.10.0100.005809%
Lip blister23.03.01.016; 07.05.01.0070.018587%Not Available
General physical health deterioration08.01.03.0180.067960%Not Available
Dysstasia15.03.05.011; 08.01.03.089; 17.02.02.0120.012779%Not Available
Lupus-like syndrome10.04.03.003; 23.03.02.004; 15.06.02.0040.008713%Not Available
Deep vein thrombosis24.01.02.003--Not Available
Dyschezia07.02.03.0050.005809%Not Available
Ligament calcification15.07.02.0010.005809%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Ocular discomfort06.08.03.0080.005809%Not Available
Lymphatic disorder01.09.01.003--Not Available
Foetor hepaticus07.01.06.026; 09.01.05.006--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.029043%Not Available
Nodule08.03.05.0020.012779%Not Available
Pulmonary mass22.02.07.0040.020330%Not Available
Pre-existing disease08.01.03.0590.005809%Not Available
Cutaneous lupus erythematosus10.04.03.007; 23.03.02.008; 15.06.02.007--Not Available
Toxic skin eruption12.03.01.073; 23.03.05.003; 10.01.01.0080.014521%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.023234%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Angiopathy24.03.02.0070.005809%Not Available
Extremity necrosis24.04.03.0120.008713%Not Available
Skin toxicity23.03.03.032; 12.03.01.0200.017426%Not Available
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