Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.[L9821, L15571]
Marketing Status approved
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0781-5667; 60715-1700; 65372-1175; 27241-063; 39822-1077; 43386-088; 0378-1640; 66039-951; 70966-0030; 47781-466; 0049-4190; 55111-099; 58032-2007; 66039-876; 43386-038; 51079-164; 0049-3190; 64980-274; 64980-275; 65862-891; 68462-572; 70594-067; 70710-1247; 60687-273; 0378-1626; 65841-830; 72572-875; 68554-0111; 75945-102; 16714-199; 43547-378; 59762-0936; 63739-008; 65162-913; 65841-831; 0904-6596; 65862-916; 71052-149; 40032-038; 43386-089; 50268-803; 0049-3180; 68083-321; 71288-027; 72578-062; 14501-0014; 52562-001; 27241-062; 43547-377; 51552-1524; 16714-198; 59762-0934; 60687-294; 65219-190; 65862-892; 70771-1413; 72843-441; 0781-5668; 63126-911; 0049-3170; 70436-029; 72578-063; 0781-3416; 0904-7024; 51552-1573; 53296-0081; 64220-140; 65015-801; 73223-005; 51079-165; 63629-8734; 0049-3160; 68462-573; 72266-131; 51407-133; 55150-321; 59762-0935
UNII JFU09I87TR
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site inflammation12.07.03.009; 08.02.03.008--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.058085%Not Available
Intestinal perforation07.04.06.002--Not Available
Intestinal ulcer07.04.06.003--Not Available
Intracranial pressure increased17.07.02.0020.005809%Not Available
Jaundice09.01.01.004; 23.03.03.030; 01.06.04.004--Not Available
Jaundice cholestatic09.01.01.0050.008713%Not Available
Keratitis06.04.02.002--
Lacrimation increased06.08.02.0040.022653%
Lentigo23.05.01.0110.037755%Not Available
Leukaemia01.10.03.001; 16.01.03.0010.049372%
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Liver disorder09.01.08.0010.066798%Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.0010.061570%Not Available
Lung infiltration22.01.02.0040.005809%Not Available
Lymphadenopathy01.09.01.002--Not Available
Lymphangitis01.09.01.005; 24.09.02.001; 11.01.15.001--Not Available
Lymphoma16.20.01.001; 01.12.01.0010.011617%Not Available
Lymphopenia01.02.02.0020.011617%Not Available
Malaise08.01.01.003--
Malignant melanoma23.08.01.001; 16.03.01.001--Not Available
Mania19.16.02.0020.011617%
Melaena07.12.02.004; 24.07.02.013--Not Available
Melanocytic naevus23.10.01.007; 16.26.01.0070.024396%Not Available
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