Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vismodegib
Drug ID BADD_D02365
Description Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.
Indications and Usage Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.
Marketing Status Prescription
ATC Code L01XJ01
DrugBank ID DB08828
KEGG ID D09992
MeSH ID C538724
PubChem ID 24776445
TTD Drug ID D03EDQ
NDC Product Code 50242-140
Synonyms HhAntag691 | NSC 747691 | NSC747691 | NSC-747691 | R 3616 | R3616 cpd | R-3616 | vismodegib | erivedge | GDC 0449 | GDC0449 | GDC-0449 | RG 3616 | RG3616 | RG-3616
Chemical Information
Molecular Formula C19H14Cl2N2O3S
CAS Registry Number 879085-55-9
SMILES CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Faeces discoloured07.01.03.0020.000799%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000139%Not Available
Fatigue08.01.01.0020.033568%
Feeling abnormal08.01.09.014--Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.007--
Flatulence07.01.04.002--
Fracture15.08.02.001; 12.04.02.001--
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.001332%
Gastric ulcer07.04.03.0020.000799%
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal carcinoma07.21.03.001; 16.13.04.0010.000139%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.0050.000139%Not Available
Gastrointestinal pain07.01.05.005--
Glaucoma06.03.01.0020.000533%
Groin pain15.03.02.0040.000533%Not Available
Haematocrit decreased13.01.05.0010.000533%Not Available
Haematoma24.07.01.001--
Haemoglobin decreased13.01.05.003--Not Available
Hair growth abnormal23.02.06.0060.000799%Not Available
Hallucination19.10.02.002--
Hallucination, auditory19.10.02.0030.000533%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.002--Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
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