Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vismodegib
Drug ID BADD_D02365
Description Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.
Indications and Usage Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.
Marketing Status Prescription
ATC Code L01XJ01
DrugBank ID DB08828
KEGG ID D09992
MeSH ID C538724
PubChem ID 24776445
TTD Drug ID D03EDQ
NDC Product Code 50242-140
Synonyms HhAntag691 | NSC 747691 | NSC747691 | NSC-747691 | R 3616 | R3616 cpd | R-3616 | vismodegib | erivedge | GDC 0449 | GDC0449 | GDC-0449 | RG 3616 | RG3616 | RG-3616
Chemical Information
Molecular Formula C19H14Cl2N2O3S
CAS Registry Number 879085-55-9
SMILES CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.002131%
Abdominal pain07.01.05.0020.006394%
Abdominal pain upper07.01.05.0030.003996%
Acne23.02.01.0010.001598%Not Available
Acne cystic23.02.01.0050.000533%Not Available
Actinic keratosis23.01.06.0010.001865%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000139%
Ageusia17.02.07.001; 07.14.03.0030.035166%Not Available
Alanine aminotransferase increased13.03.01.0030.002398%
Alopecia23.02.02.0010.071665%
Amenorrhoea21.01.02.001; 05.05.01.0020.003463%
Amnesia19.20.01.001; 17.03.02.0010.001598%
Anaemia01.03.02.0010.005861%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anosmia22.04.03.006; 17.04.04.0010.001332%
Anxiety19.06.02.002--
Aphasia17.02.03.001; 19.21.01.0010.000799%
Arrhythmia02.03.02.0010.001598%Not Available
Arthralgia15.01.02.0010.009591%
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.0060.001865%
Aspiration22.02.07.0070.000139%
Asthenia08.01.01.0010.010656%Not Available
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.0030.000533%
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.0050.004263%
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