Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vincristine
Drug ID BADD_D02360
Description Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Indications and Usage Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Marketing Status Prescription; Discontinued
ATC Code L01CA02
DrugBank ID DB00541
KEGG ID D08679
MeSH ID D014750
PubChem ID 5978
TTD Drug ID D09QVV
NDC Product Code Not Available
Synonyms Vincristine | Leurocristine | Vincristine Sulfate | Sulfate, Vincristine | cellcristin | Citomid | Vincristin medac | Oncovin | Oncovine | Onkocristin | Vincasar | Farmistin | Vincasar PFS | PFS, Vincasar | Vincristin Bristol | Vintec | Vincrisul
Chemical Information
Molecular Formula C46H56N4O10
CAS Registry Number 57-22-7
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.000799%
Abdominal pain07.01.05.0020.001865%
Abscess11.01.08.0010.000533%Not Available
Acute abdomen07.01.06.015--Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000208%Not Available
Acute respiratory failure14.01.04.004; 22.02.06.0010.000208%Not Available
Adrenal disorder05.01.03.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.003--Not Available
Anaemia01.03.02.0010.001598%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anuria20.01.03.0020.000139%Not Available
Anxiety19.06.02.002--
Aplasia08.03.04.003; 03.02.01.0020.000533%Not Available
Areflexia17.02.01.0010.000533%Not Available
Ascites02.05.04.002; 09.01.05.003; 07.07.01.0010.000533%
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.001332%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atonic urinary bladder20.03.03.004; 17.05.01.010--Not Available
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.001--Not Available
Blindness cortical17.17.01.017; 06.02.02.004--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Cardiac arrest02.03.04.0010.000208%
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
The 1th Page    1 2 3 4 5    Next   Last    Total 7 Pages