Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Verapamil
Drug ID BADD_D02348
Description Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in the early 1960s.[A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications.[L8791] Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.[A188435]
Indications and Usage For the treatment of hypertension, angina, and cluster headache prophylaxis.
Marketing Status Prescription; Discontinued
ATC Code C08DA01
DrugBank ID DB00661
KEGG ID D02356
MeSH ID D014700
PubChem ID 2520
TTD Drug ID D0R0FE
NDC Product Code 70966-0029
Synonyms Verapamil | Iproveratril | Cordilox | Dexverapamil | Verapamil Hydrochloride | Hydrochloride, Verapamil | Finoptin | Izoptin | Isoptine | Isoptin | Lekoptin | Calan | Falicard
Chemical Information
Molecular Formula C27H38N2O4
CAS Registry Number 52-53-9
SMILES CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000281%
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anuria20.01.03.0020.000861%Not Available
Arrhythmia02.03.02.0010.001292%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.000861%
Atrioventricular block02.03.01.0020.000169%Not Available
Atrioventricular block complete02.03.01.0030.002369%
Bezoar07.11.01.0080.000431%Not Available
Blood pressure decreased13.14.03.0020.000225%Not Available
Blood prolactin increased13.10.03.002--Not Available
Bradycardia02.03.02.0020.002584%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block left02.03.01.0070.000646%Not Available
Bundle branch block right02.03.01.0110.000431%Not Available
Cardiac arrest02.03.04.0010.000618%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000169%Not Available
Cardiogenic shock02.05.01.003; 24.06.02.0060.001723%Not Available
Cardiomyopathy02.04.01.0010.000431%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000431%
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cholecystitis acute09.03.01.0030.000431%Not Available
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