Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valrubicin
Drug ID BADD_D02330
Description Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Indications and Usage For the treatment of cancer of the bladder.
Marketing Status Prescription
ATC Code L01DB09
DrugBank ID DB00385
KEGG ID D02697
MeSH ID C016163
PubChem ID 454216
TTD Drug ID D07IPB
NDC Product Code 27831-005; 67979-001; 72027-005; 77391-005
Synonyms valrubicin | N-trifluoroacetyladriamycin 14-valerate | Valtaxin | Valstar | AD 32 | AD-32 | NSC-246131
Chemical Information
Molecular Formula C34H36F3NO13
CAS Registry Number 56124-62-0
SMILES CCCCC(=O)OCC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)OC5CC(C(C(O 5)C)O)NC(=O)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nocturia20.02.03.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain08.01.08.0040.000799%
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Proctalgia07.03.02.001--
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.000799%
Rash23.03.13.0010.000799%Not Available
Skin irritation23.03.04.009--Not Available
Urethral pain20.02.02.014--Not Available
Urethritis11.01.14.008; 20.07.02.001--
Urge incontinence20.02.02.0080.002931%Not Available
Urinary incontinence20.02.02.010; 17.05.01.0080.001066%
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urine flow decreased20.02.02.012--Not Available
Vomiting07.01.07.003--
Bladder spasm20.02.02.0130.000799%
Musculoskeletal discomfort15.03.04.001--Not Available
Thermal burn12.05.04.001--
Rectal tenesmus15.05.03.011; 07.03.03.001--Not Available
Vasodilation procedure25.03.01.001--Not Available
Ill-defined disorder08.01.03.0490.000799%Not Available
Disease progression08.01.03.0380.000139%
Drug intolerance08.06.01.0130.000799%Not Available
Urethritis noninfective20.07.02.002--Not Available
Cystitis noninfective20.03.02.001--
Anorectal discomfort07.03.03.003--Not Available
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