Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Unoprostone isopropyl
Drug ID BADD_D02317
Description Unoprostone isopropyl is a prostaglandin analogue. Ophthalmic Solution 0.15% is a synthetic docosanoid. Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate. The main indication of Unoprostane is treatment of glucoma.
Indications and Usage For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Discontinued
ATC Code S01EE02
DrugBank ID DB06826
KEGG ID D01452
MeSH ID C072630
PubChem ID 5282175
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms isopropyl unoprostone | unoprostone isopropyl | isopropyl Z-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)hept-5-enoate, D- | isopropyl 20-ethyl-9alpha,11alpha-dihydroxy-15-keto-cis-delta-5-prostanoate | Rescula | Eescula | UF 021 | UF-021
Chemical Information
Molecular Formula C25H44O5
CAS Registry Number 120373-24-2
SMILES CCCCCCCC(=O)CCC1C(CC(C1CC=CCCCC(=O)OC(C)C)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Keratitis06.04.02.002--
Lacrimation disorder06.08.02.010--Not Available
Optic atrophy06.09.02.001--Not Available
Pain08.01.08.004--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photophobia17.17.02.006; 06.01.01.004--
Pruritus23.03.12.001--
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sinusitis11.01.13.005; 22.07.03.007--
Skin hyperpigmentation23.05.01.003--
Skin irritation23.03.04.009--Not Available
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.06.008--Not Available
Vitreous disorder06.08.03.006--Not Available
Growth of eyelashes06.06.04.007--Not Available
Iris hyperpigmentation06.06.06.001--Not Available
Eyelid disorder23.03.03.028; 06.08.03.010--Not Available
Lacrimal disorder06.08.02.005--Not Available
Sensation of foreign body08.01.09.002--Not Available
Lacrimal structural disorder06.06.04.013--Not Available
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