Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Unoprostone
Drug ID BADD_D02316
Description Unoprostone isopropyl is a prostaglandin analogue. Ophthalmic Solution 0.15% is a synthetic docosanoid. Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate. The main indication of Unoprostane is treatment of glucoma.
Indications and Usage For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Discontinued
ATC Code S01EE02
DrugBank ID DB06826
KEGG ID D08661
MeSH ID C072630
PubChem ID 5311236
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms isopropyl unoprostone | unoprostone isopropyl | isopropyl Z-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)hept-5-enoate, D- | isopropyl 20-ethyl-9alpha,11alpha-dihydroxy-15-keto-cis-delta-5-prostanoate | Rescula | Eescula | UF 021 | UF-021
Chemical Information
Molecular Formula C22H38O5
CAS Registry Number 120373-36-6
SMILES CCCCCCCC(=O)CCC1C(CC(C1CC=CCCCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Palpitations02.01.02.003--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photophobia17.17.02.006; 06.01.01.004--
Pruritus23.03.12.001--
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sinusitis11.01.13.005; 22.07.03.007--
Skin hyperpigmentation23.05.01.003--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.06.008--Not Available
Vitreous disorder06.08.03.006--Not Available
Vomiting07.01.07.003--
Iris hyperpigmentation06.06.06.001--Not Available
Eyelid disorder06.08.03.010; 23.03.03.028--Not Available
Lacrimal disorder06.08.02.005--Not Available
Sensation of foreign body08.01.09.002--Not Available
Lacrimal structural disorder06.06.04.013--Not Available
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