Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Trovafloxacin mesylate
Drug ID BADD_D02308
Description Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones. Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Indications and Usage For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis.
Marketing Status approved; investigational; withdrawn
ATC Code J01MA13
DrugBank ID DB00685
KEGG ID D02123
MeSH ID C080163
PubChem ID 62960
TTD Drug ID D03WPA
NDC Product Code Not Available
UNII 0P1LKO80WN
Synonyms trovafloxacin | CP 99219 | CP-99,219 | CP-99219 | CP 99,219
Chemical Information
Molecular Formula C21H19F3N4O6S
CAS Registry Number 147059-75-4
SMILES CS(=O)(=O)O.C1C2C(C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alcohol intolerance14.02.01.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Anorectal disorder07.03.01.001--Not Available
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Breath odour07.01.06.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Change of bowel habit07.02.03.002--Not Available
Cheilitis23.03.03.025; 07.05.01.001--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Clostridium difficile colitis11.02.02.004; 07.19.01.004--Not Available
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