Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tropicamide
Drug ID BADD_D02303
Description Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors.[A230103] Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures.[A229958] It is also used in combination with [hydroxyamphetamine] for the same indication.[L32178] Oral tropicamide has been investigated as a potential drug to relieve sialorrhea in patients with Parkinson's Disease.[A229958]
Indications and Usage Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
Marketing Status Prescription; Discontinued
ATC Code S01FA06
DrugBank ID DB00809
KEGG ID D00397
MeSH ID D014331
PubChem ID 5593
TTD Drug ID D09PNY
NDC Product Code 51552-1016; 52286-0010; 17478-101; 70518-2759; 70069-121; 0404-7192; 24208-585; 38779-0273; 61314-354; 73309-019; 24208-590; 0065-0355; 0998-0355; 62991-2940; 61314-355; 17478-102; 57419-0002; 51927-2670
Synonyms Tropicamide | N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide | N-Ethyl-N-(4-pyridylmethyl)tropamide | Minims Tropicamide | Mydriafair | Mydriaticum | Mydrum | Ocu-Tropic | Ocu Tropic | OcuTropic | Tropicacyl | Tropicamide Faure | Tropicamide Minims | Tropicamide Monofree | Tropicamide Monohydrochloride, (R)-Isomer | Tropicamide Monohydrochloride, (S)-Isomer | Tropicamide, (+-)-Isomer | Tropicamide, (R)-Isomer | Tropicamide, (S)-Isomer | Colircusi Tropicamida | Mydral
Chemical Information
Molecular Formula C17H20N2O2
CAS Registry Number 1508-75-4
SMILES CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.016514%
Tachycardia02.03.02.007--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Unresponsive to stimuli17.02.05.0310.011010%Not Available
Vasoconstriction24.04.03.008; 23.06.05.007--Not Available
Vision blurred06.02.06.007; 17.17.01.0100.038533%
Visual acuity reduced17.17.01.011; 06.02.03.0010.016514%
Vital dye staining cornea present13.07.04.010--Not Available
Vomiting07.01.07.0030.022019%
Balance disorder17.02.02.0070.011010%Not Available
Cardiopulmonary failure22.02.06.004; 02.05.01.004--Not Available
Corneal irritation06.04.02.010--Not Available
Abnormal behaviour19.01.01.001--Not Available
Psychotic disorder19.03.01.002--
Superficial injury of eye12.01.04.032; 06.11.04.0010.016514%Not Available
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