Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tromethamine
Drug ID BADD_D02302
Description An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
Indications and Usage For the prevention and correction of metabolic acidosis.
Marketing Status Prescription; Discontinued
ATC Code B05BB03; B05XX02
DrugBank ID DB03754
KEGG ID D00396
MeSH ID D014325
PubChem ID 6503
TTD Drug ID D03ZFN
NDC Product Code 64173-101; 0409-1593; 64173-204; 42533-114
Synonyms Tromethamine | Tris Buffer | Tri(hydroxymethyl)aminomethane | Trometamol | Tris(hydroxymethyl)aminomethane | Trisamine | Trizma | Tris-Magnesium(II)-Potassium Chloride Buffer | Tris-Mg(II)-KCl Buffer
Chemical Information
Molecular Formula C4H11NO3
CAS Registry Number 77-86-1
SMILES C(C(CO)(CO)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood glucose decreased13.02.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Extravasation08.01.03.008--Not Available
Fluid overload14.05.06.001; 02.05.04.004--Not Available
Hepatic necrosis09.01.07.002--
Hypervolaemia14.05.06.003--Not Available
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Infection11.01.08.002--Not Available
Injection site infection12.07.03.008; 11.01.08.005; 08.02.03.019--Not Available
Peripheral vascular disorder24.03.01.003--Not Available
Phlebitis12.02.01.002; 24.05.03.001--
Pyrexia08.05.02.003--
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Vasospasm24.04.02.002--Not Available
Venous thrombosis24.01.01.008--Not Available
Pulmonary function test decreased13.19.01.001--Not Available
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