| Drug Name |
Trimethoprim hydrochloride |
| Drug ID |
BADD_D02291 |
| Description |
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707] |
| Indications and Usage |
For the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller's diarrhea. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
J01EA01 |
| DrugBank ID |
DB00440
|
| KEGG ID |
D11085
|
| MeSH ID |
D014295
|
| PubChem ID |
173769
|
| TTD Drug ID |
D0AO5H
|
| NDC Product Code |
38779-0770; 51927-1693; 64374-001; 43386-330; 63629-7731; 49452-7925; 60592-716; 51407-257; 51862-486; 72672-001; 65863-0008; 40032-330; 62991-2072; 65863-0004; 57451-1111; 38779-0270; 57451-1202 |
| Synonyms |
Trimethoprim | Trimpex | Proloprim |
