Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Trihexyphenidyl hydrochloride
Drug ID BADD_D02285
Description Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects.[L31843] It has largely been replaced by drugs such as [levodopa].[L31843] Trihexyphenidyl was granted FDA approval on 13 May 1949.[L31768]
Indications and Usage Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.
Marketing Status Prescription; Discontinued
ATC Code N04AA01
DrugBank ID DB00376
KEGG ID D00787
MeSH ID D014282
PubChem ID 66007
TTD Drug ID D09GFL
NDC Product Code 17337-0038; 51407-265; 70954-211; 0591-5335; 0121-0658; 70518-1140; 16571-160; 70518-1612; 70518-2878; 69452-241; 70518-1657; 69452-242; 58159-064; 0591-5337; 50090-5205; 70518-1021; 70954-212; 63850-0021; 50090-2994; 63850-0022; 70518-3288; 16571-161; 70518-2409; 70518-2410; 71554-022; 70518-2880; 70518-3268; 51407-266
Synonyms Trihexyphenidyl | Benzhexol | Artane | Cyclodol | Hipokinon | Trihexyphenidyl Hydrochloride Elixir | Parkopan | Trihexane | Trihexidyl Hydrochloride | Trihexyphenidyl Hydrochloride | Apo-Trihex | Apo Trihex | ApoTrihex | Parkinane
Chemical Information
Molecular Formula C20H32ClNO
CAS Registry Number 52-49-3
SMILES C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Angle closure glaucoma06.03.01.001--Not Available
Arteriosclerosis24.04.02.001--Not Available
Asthenia08.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Delusion19.10.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Euphoric mood19.04.02.006--
Hallucination19.10.02.002--
Headache17.14.01.001--
Ileus paralytic07.02.05.001--Not Available
Intestinal dilatation07.02.02.010--Not Available
Intracranial pressure increased17.07.02.002--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Paranoia19.05.01.005--Not Available
Parkinsonism17.01.05.003--Not Available
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Urinary hesitation20.02.02.009--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Idiosyncratic drug reaction08.06.01.002--Not Available
Abnormal behaviour19.01.01.001--Not Available
Psychiatric symptom19.01.02.001--Not Available
Urinary tract obstruction20.08.01.004--
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