Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Trihexyphenidyl
Drug ID BADD_D02284
Description Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects.[L31843] It has largely been replaced by drugs such as [levodopa].[L31843] Trihexyphenidyl was granted FDA approval on 13 May 1949.[L31768]
Indications and Usage Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.
Marketing Status Prescription; Discontinued
ATC Code N04AA01
DrugBank ID DB00376
KEGG ID D08638
MeSH ID D014282
PubChem ID 5572
TTD Drug ID D09GFL
NDC Product Code 63850-6535
Synonyms Trihexyphenidyl | Benzhexol | Artane | Cyclodol | Hipokinon | Trihexyphenidyl Hydrochloride Elixir | Parkopan | Trihexane | Trihexidyl Hydrochloride | Trihexyphenidyl Hydrochloride | Apo-Trihex | Apo Trihex | ApoTrihex | Parkinane
Chemical Information
Molecular Formula C20H31NO
CAS Registry Number 144-11-6
SMILES C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Accommodation disorder06.02.04.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Angle closure glaucoma06.03.01.001--Not Available
Asthenia08.01.01.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Chorea17.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cycloplegia17.17.02.003; 06.05.03.002--Not Available
Delusion19.10.01.001--
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry skin23.03.03.001--
Euphoric mood19.04.02.006--
Feeling abnormal08.01.09.014--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperkinesia17.01.02.008--Not Available
Ileus paralytic07.02.05.001--Not Available
Intraocular pressure increased13.07.04.002--Not Available
Memory impairment17.03.02.003; 19.20.01.003--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.005--Not Available
Paranoia19.05.01.005--Not Available
Parotitis11.01.04.001; 07.06.04.001--Not Available
Rash23.03.13.001--Not Available
Sinus bradycardia02.03.03.009--
Somnolence19.02.05.003; 17.02.04.006--
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