Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 62332-516; 68245-0008; 0703-0666; 0703-0686; 0781-3427; 58159-041; 0781-3420; 66302-120; 0703-0676; 62332-515; 66302-110; 42023-206; 42023-208; 42023-207; 62332-517; 11014-0094; 81861-0029; 62332-514; 66302-102; 54893-0024; 66302-300; 66302-302; 14501-0015; 66302-206; 0781-3425; 66302-350; 66302-105; 66302-101; 42023-209; 0781-3430; 66302-310; 66302-325
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.0010.043592%
Neck pain15.03.04.0090.001669%
Neoplasm malignant16.16.01.001--Not Available
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.002040%Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Night sweats23.02.03.006; 08.01.03.0310.001113%Not Available
Nightmare19.02.03.003--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema14.05.06.010; 08.01.07.0060.007234%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.012614%
Oliguria20.01.03.0040.000742%Not Available
Oral candidiasis11.03.03.004; 07.05.07.0010.000556%Not Available
Oral pain07.05.03.002--
Orthopnoea22.02.01.020; 02.01.03.0060.000556%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Oxygen saturation decreased13.02.01.0040.012057%Not Available
Pain08.01.08.0040.014098%
Pain in extremity15.03.04.0100.013541%
Pain in jaw15.02.01.0030.012243%Not Available
Painful respiration22.02.08.0080.000371%Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.001113%Not Available
Palpitations02.01.02.0030.007420%
Pancreatic disorder07.18.02.0010.000371%Not Available
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Panic attack19.06.04.001--Not Available
Paraesthesia17.02.06.005--
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