Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sinus congestion22.04.06.0010.000461%Not Available
Sinus headache22.12.03.022; 17.14.01.0020.000419%
Sinusitis22.07.03.007; 11.01.13.005--
Skin irritation23.03.04.0090.000485%Not Available
Skin striae23.01.05.0020.000280%Not Available
Skin warm23.03.03.0140.000461%Not Available
Sluggishness08.01.01.0040.000559%Not Available
Small intestinal obstruction07.13.06.0010.000123%
Sputum discoloured22.02.03.0100.000642%Not Available
Sputum increased22.02.03.0070.000181%Not Available
Sudden death08.04.01.003; 02.03.04.0130.000123%
Supraventricular tachycardia02.03.03.0120.000535%
Swelling08.01.03.0150.002278%Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.004803%
Systemic lupus erythematosus10.04.03.004; 23.03.02.006; 15.06.02.0030.000691%Not Available
Tachycardia02.03.02.0070.002155%Not Available
Tearfulness19.15.02.0050.000181%Not Available
Tension19.06.02.005--Not Available
Throat irritation22.12.03.029; 07.05.05.0370.006744%Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Thrombosis24.01.01.006--Not Available
Thyroid disorder05.02.01.0020.000082%Not Available
Tooth loss12.01.17.026; 07.09.09.0010.000280%Not Available
Toothache07.09.06.0010.000502%
Trismus17.01.03.004; 15.05.04.0040.000123%
Unresponsive to stimuli17.02.05.0310.000493%Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Uterine leiomyoma21.07.02.004; 16.04.02.0010.000222%Not Available
Vasodilatation24.03.02.003; 23.06.05.0060.000181%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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