Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 62332-516; 68245-0008; 0703-0666; 0703-0686; 0781-3427; 58159-041; 0781-3420; 66302-120; 0703-0676; 62332-515; 66302-110; 42023-206; 42023-208; 42023-207; 62332-517; 11014-0094; 81861-0029; 62332-514; 66302-102; 54893-0024; 66302-300; 66302-302; 14501-0015; 66302-206; 0781-3425; 66302-350; 66302-105; 66302-101; 42023-209; 0781-3430; 66302-310; 66302-325
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Herpes zoster23.09.03.002; 11.05.02.003--
Hip fracture15.08.03.001; 12.04.01.0010.002226%
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.0020.020590%
Hypotonia17.05.02.002; 15.05.04.0080.000556%Not Available
Hypovolaemia14.05.05.0020.001113%Not Available
Hypovolaemic shock24.06.02.0170.000145%Not Available
Hypoxia22.02.02.0030.015025%
Ileus07.13.01.001--
Impaired gastric emptying07.02.02.0040.000371%
Incontinence07.01.06.011; 20.02.02.004; 17.05.01.0060.000371%Not Available
Infection11.01.08.0020.001694%Not Available
Influenza22.07.02.001; 11.05.03.0010.005565%Not Available
Influenza like illness08.01.03.0100.002597%
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.002040%Not Available
Intestinal obstruction07.13.01.002--Not Available
Intestinal perforation07.04.06.0020.000097%Not Available
Intussusception07.13.01.0080.000371%Not Available
Irritability08.01.03.011; 19.04.02.013--
Joint effusion15.01.02.0050.000371%
Joint swelling15.01.02.004--Not Available
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