Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 62332-516; 68245-0008; 0703-0666; 0703-0686; 0781-3427; 58159-041; 0781-3420; 66302-120; 0703-0676; 62332-515; 66302-110; 42023-206; 42023-208; 42023-207; 62332-517; 11014-0094; 81861-0029; 62332-514; 66302-102; 54893-0024; 66302-300; 66302-302; 14501-0015; 66302-206; 0781-3425; 66302-350; 66302-105; 66302-101; 42023-209; 0781-3430; 66302-310; 66302-325
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspnoea exertional22.02.01.005; 02.01.03.0030.008533%Not Available
Eating disorder19.09.01.008; 14.03.01.008--Not Available
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.002--Not Available
Eczema23.03.04.0060.000556%
Electrolyte imbalance14.05.01.0020.000371%Not Available
Emphysema22.01.02.0020.000097%Not Available
Empyema11.01.08.0200.000371%Not Available
Encephalopathy17.13.02.001--
Endocarditis11.01.16.001; 02.09.01.0010.000097%
Epistaxis24.07.01.005; 22.04.03.0010.003895%
Eructation07.01.02.0030.000556%
Erythema23.03.06.001--Not Available
Eye irritation06.04.05.003--Not Available
Eye swelling06.08.03.003--Not Available
Faeces discoloured07.01.03.002--Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000145%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.007605%Not Available
Feeling cold08.01.09.0080.001669%Not Available
Feeling hot08.01.09.0090.001298%Not Available
Feeling jittery08.01.09.0160.000556%Not Available
Flank pain08.01.08.007; 20.02.03.006; 15.03.04.0030.000742%
Flatulence07.01.04.002--
Fluid overload14.05.06.001; 02.05.04.0040.019292%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.019106%Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.0020.012614%
Food allergy10.01.01.0120.000371%Not Available
Foot fracture15.08.03.012; 12.04.01.012--Not Available
Frequent bowel movements07.02.04.0020.000556%Not Available
Fungal infection11.03.05.001--Not Available
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