ADReCS

Pharmaceutical Information

Drug Name	Treprostinil
Drug ID	BADD_D02268
Description	Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage	For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status	approved; investigational
ATC Code	B01AC21
DrugBank ID	DB00374
KEGG ID	D06213
MeSH ID	C427248
PubChem ID	6918140
TTD Drug ID	D01WUA
NDC Product Code	0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII	RUM6K67ESG
Synonyms	treprostinil \| ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate \| treprostinil sodium \| trepostinil sodium \| Orenitram \| UT-15 \| UT-15C \| Remodulin \| treprostinil diolamine \| treprostinil diolamin \| treprostinil diethanolamine

Chemical Information

Molecular Formula	C23H34O5
CAS Registry Number	81846-19-7
SMILES	CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Hepatic failure	09.01.03.002	0.000576%
Hernia	08.01.04.001	0.000864%		Not Available
Hiccups	22.12.01.001; 07.01.06.009	0.000280%
Hypersomnia	19.02.05.001; 17.15.01.001	0.000502%
Hyperventilation	22.02.01.006; 19.01.02.004	0.000222%		Not Available
Hypervolaemia	02.05.04.019; 14.05.06.003	0.006522%		Not Available
Hypokalaemia	14.05.03.002	-	-
Hypotension	24.06.03.002	0.009960%
Hypotonia	17.05.02.002; 15.05.04.008	0.000123%		Not Available
Hypovolaemia	14.05.05.002	0.000345%		Not Available
Hypovolaemic shock	24.06.02.017	0.000123%		Not Available
Hypoxia	22.02.02.003	0.005354%
Idiopathic pulmonary fibrosis	22.01.02.014; 10.02.01.034	0.000123%		Not Available
Impaired gastric emptying	07.02.02.004	0.000123%
Incontinence	20.02.02.004; 17.05.01.006; 07.01.06.011	0.000222%		Not Available
Increased tendency to bruise	24.07.06.012; 23.06.01.009; 01.01.03.005	0.000181%		Not Available
Infection	11.01.08.002	-	-	Not Available
Influenza	22.07.02.001; 11.05.03.001	-	-	Not Available
Influenza like illness	08.01.03.010	0.001883%
Initial insomnia	19.02.01.005; 17.15.03.005	0.000419%		Not Available
Injection site bruising	12.07.03.042; 08.02.03.042; 24.07.06.017; 23.03.11.015	0.000263%		Not Available
Injection site erythema	08.02.03.001; 23.03.06.015; 12.07.03.001	0.001974%		Not Available
Injection site extravasation	12.07.03.002; 08.02.03.002	0.001028%		Not Available
Injection site haemorrhage	24.07.01.010; 12.07.03.005; 08.02.03.005	0.002031%		Not Available
Injection site induration	08.02.03.007; 12.07.03.007	0.000181%		Not Available
Injection site irritation	12.07.03.027; 08.02.03.027	0.000806%		Not Available
Injection site oedema	12.07.03.024; 08.02.03.024	0.000123%		Not Available
Injection site pain	08.02.03.010; 12.07.03.011	0.002360%		Not Available
Injection site pruritus	12.07.03.014; 08.02.03.013; 23.03.12.007	0.001168%		Not Available
Injection site rash	23.03.13.010; 12.07.03.032; 08.02.03.032	0.000699%		Not Available

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