Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 62332-516; 68245-0008; 0703-0666; 0703-0686; 0781-3427; 58159-041; 0781-3420; 66302-120; 0703-0676; 62332-515; 66302-110; 42023-206; 42023-208; 42023-207; 62332-517; 11014-0094; 81861-0029; 62332-514; 66302-102; 54893-0024; 66302-300; 66302-302; 14501-0015; 66302-206; 0781-3425; 66302-350; 66302-105; 66302-101; 42023-209; 0781-3430; 66302-310; 66302-325
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000532%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000629%Not Available
Cardiomegaly02.04.02.0010.000145%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.0010.005936%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.006678%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.021147%Not Available
Chills15.05.03.016; 08.01.09.0010.004266%
Cholecystitis09.03.01.0010.000927%
Cholecystitis acute09.03.01.0030.000371%Not Available
Cholelithiasis09.03.01.0020.001113%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.001452%Not Available
Circulatory collapse24.06.02.0010.001113%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.000927%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000742%Not Available
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.005--Not Available
Coma17.02.09.001--Not Available
Concussion17.11.01.004; 12.01.10.0050.000371%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Congenital diaphragmatic hernia22.09.02.003; 07.16.01.003; 03.16.03.0010.000371%Not Available
Constipation07.02.02.001--
Cor pulmonale22.06.01.003; 02.05.03.001; 24.08.03.0010.000194%Not Available
Cough22.02.03.0010.019663%
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.001669%
Death08.04.01.0010.026615%
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