Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Faeces soft07.01.03.0080.000559%Not Available
Complication associated with device08.07.01.0110.002319%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000658%
Device related thrombosis24.01.01.027; 08.07.05.0010.000123%Not Available
Anal incontinence17.05.01.021; 07.01.06.0290.000362%
Anaemia of chronic disease01.03.04.0020.000082%Not Available
Cardiac failure chronic02.05.01.0090.000164%Not Available
Chronic respiratory failure22.02.06.005; 14.01.04.0050.000247%Not Available
Cor pulmonale chronic24.08.03.005; 22.06.01.005; 02.05.03.0050.000164%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.0030.000082%Not Available
Pneumothorax spontaneous22.05.02.0070.000082%Not Available
Pulmonary sarcoidosis22.01.01.023; 10.02.06.0030.000280%Not Available
Restrictive pulmonary disease22.01.02.0250.000123%Not Available
Terminal state08.01.03.0790.000082%Not Available
Live birth18.08.02.0070.000082%Not Available
Tracheal stenosis22.04.07.0100.000082%
Right ventricular dysfunction02.04.02.0330.000082%
Acute right ventricular failure02.05.03.0030.000164%Not Available
Weight bearing difficulty15.03.05.0340.000181%Not Available
Portopulmonary hypertension22.06.01.006; 09.01.06.026; 24.08.03.0060.000123%Not Available
Apparent death08.01.03.0620.000082%Not Available
Heart valve incompetence02.07.02.0030.000082%Not Available
Pulmonary hypertensive crisis24.08.03.007; 22.06.01.0070.000164%Not Available
Ventilation perfusion mismatch22.02.07.0180.000403%Not Available
Sensitivity to weather change08.01.03.0770.000280%Not Available
Gastrointestinal polyp haemorrhage16.05.01.008; 24.07.02.046; 07.20.01.0110.000082%Not Available
Pulmonary pain22.12.01.0100.000362%Not Available
Internal haemorrhage24.07.01.0720.000288%Not Available
Fine motor skill dysfunction17.01.02.0200.000280%Not Available
End stage renal disease20.01.03.0190.000164%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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