Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Catheter site pain08.02.02.004; 12.07.02.0040.000724%Not Available
Paranasal sinus discomfort22.12.03.0180.000419%Not Available
Drug tolerance decreased08.06.01.0240.000321%Not Available
Musculoskeletal discomfort15.03.04.0010.000362%Not Available
Injection site swelling12.07.03.018; 08.02.03.0170.000625%Not Available
Secretion discharge08.01.03.0190.000362%Not Available
Infusion site induration08.02.05.009; 12.07.05.0100.001727%Not Available
Infusion site pain12.07.05.002; 08.02.05.0140.016959%Not Available
Infusion site warmth08.02.05.011; 12.07.05.0120.001727%Not Available
Infusion site swelling08.02.05.002; 12.07.05.0030.005601%Not Available
Infusion site pruritus08.02.05.004; 23.03.12.006; 12.07.05.0050.002262%Not Available
Infusion site oedema12.07.05.013; 08.02.05.0120.000567%Not Available
Skin burning sensation17.02.06.009; 23.03.03.0210.000461%Not Available
Infusion site reaction12.07.05.006; 08.02.05.0050.001012%Not Available
Infusion site infection12.07.05.019; 11.01.15.003; 08.02.05.019--Not Available
Haemorrhage24.07.01.002--Not Available
Infusion site inflammation12.07.05.020; 08.02.05.0200.000724%Not Available
Pulmonary mass22.02.07.0040.000222%Not Available
Pharyngeal erythema22.04.05.0100.000280%Not Available
Temperature intolerance08.01.09.0220.000321%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.000543%Not Available
Paranasal sinus hypersecretion22.04.06.0040.000600%Not Available
Pulseless electrical activity02.03.04.0200.000164%Not Available
Pseudomonal sepsis11.02.12.003--Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.000740%Not Available
Haemobilia24.07.01.049; 09.01.08.0090.000082%Not Available
Ventricular dysfunction02.04.02.0050.000181%Not Available
Infusion site rash23.03.13.018; 12.07.05.017; 08.02.05.0170.001061%Not Available
Induration08.01.03.020--Not Available
Limb discomfort15.03.04.0140.001382%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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