Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tranexamic acid
Drug ID BADD_D02261
Description Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.[L31883] It was first patented in 1957[A230108] and received its initial US approval in 1986.[L31858]
Indications and Usage Dunn CJ, Goa KL: Tranexamic acid: a review of its use in surgery and other indications. Drugs. 1999 Jun;57(6):1005-32.
Marketing Status Prescription; Discontinued
ATC Code B02AA02
DrugBank ID DB00302
KEGG ID D01136
MeSH ID D014148
PubChem ID 5526
TTD Drug ID D05HXX
NDC Product Code 12079-2001; 71052-166; 42571-314; 51754-0108; 67457-197; 71335-1957; 69918-301; 60505-6169; 70860-400; 0591-3720; 63629-8838; 67850-041; 50090-5072; 0013-1114; 51552-0513; 38779-3211; 42571-189; 49452-7877; 67850-042; 81999-0001; 43066-008; 72485-107; 68382-891; 39822-1000; 55150-188; 72611-760; 50090-4530; 49452-7876; 12848-1004; 71335-1981; 70121-1398; 51662-1532; 65388-0156; 61990-0611; 63323-563; 65145-106; 23155-166; 38779-2794; 81284-611; 70771-1085; 73309-178; 57218-951; 63629-8599; 51927-0022; 63759-0038; 62991-3131; 69918-300; 17478-017; 0517-0960; 81284-612; 17478-018; 62559-265; 68083-160; 55566-2110; 23155-524
Synonyms Tranexamic Acid | AMCHA | trans-4-(Aminomethyl)cyclohexanecarboxylic Acid | t-AMCHA | AMCA | Anvitoff | Cyklokapron | Ugurol | KABI 2161 | Spotof | Transamin | Amchafibrin | Exacyl
Chemical Information
Molecular Formula C8H15NO2
CAS Registry Number 701-54-2
SMILES C1CC(CCC1CN)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ischaemic cerebral infarction24.04.06.013; 17.08.01.0220.007455%Not Available
Cardiac disorder02.01.01.003--Not Available
Embolism24.01.01.009--
Ischaemic stroke24.04.06.010; 17.08.01.0180.107164%Not Available
Mediastinal disorder22.09.03.001--Not Available
Poisoning12.03.01.004--Not Available
Ill-defined disorder08.01.03.049--Not Available
Urinary tract obstruction20.08.01.0040.014288%
Obstructive airways disorder22.03.01.0110.014288%Not Available
Haemophilia01.01.01.009; 03.15.01.006--Not Available
Renal impairment20.01.03.0100.057154%Not Available
Acute kidney injury20.01.03.0160.057154%
Posterior reversible encephalopathy syndrome17.13.02.0070.021433%
Procedural haemorrhage24.07.01.053; 12.02.05.0360.014288%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.014288%Not Available
Peripheral artery thrombosis24.01.02.0100.035721%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.005591%
Cerebral artery thrombosis24.01.04.008; 17.08.01.0260.005591%Not Available
Obstructive uropathy20.01.05.0040.028577%Not Available
Respiratory rate increased13.15.01.0040.021433%Not Available
Urinary bladder haemorrhage24.07.01.086; 20.03.01.0230.005591%Not Available
Atrial thrombosis24.01.05.005; 02.01.01.0130.028577%Not Available
Live birth18.08.02.0070.014288%Not Available
Sopor19.02.04.002; 17.02.04.0210.014288%Not Available
Vascular stent stenosis24.04.02.028; 08.07.05.0070.014288%Not Available
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