| Pharmaceutical Information |
| Drug Name |
Tocophersolan |
| Drug ID |
BADD_D02235 |
| Description |
D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of vitamin E in children suffering from cholestasis [L2371]. Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by _hepatocytes_ (liver cells) or obstruction [L2374], [L2375].
Tocofersolan is a polyethylene glycol derivative of α-tocopherol and synthetic water-soluble version of [DB11251]. Tocofersolan is an oral treatment of vitamin E deficiency due to digestive malabsorption in pediatric patients with congenital chronic cholestasis or hereditary chronic cholestasis. It was approved by the European Medicines Agency (EMA) in June 2009 under the market name Vedrop. Moreover, the agent is capable of demonstrating antioxidant effects that make it a popular component to include in cosmetics and pharmaceuticals as well.
In addition to the above, tocofersolan has been studied as a promising application as an absorption enhancer in drug delivery [MSDS]. |
| Indications and Usage |
years of age. [EMA] |
| Marketing Status |
Not Available |
| ATC Code |
A11HA08 |
| DrugBank ID |
DB11635
|
| KEGG ID |
D06174
|
| MeSH ID |
C014225
|
| PubChem ID |
71406
|
| TTD Drug ID |
D08CVC
|
| NDC Product Code |
Not Available |
| Synonyms |
tocophersolan | mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) succinate polyethylene glycol monoester | poly(oxy-1,2-ethanediyl), alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy- | tocofersolan | tocopherol polyethylene glycol succinate | vitamin E-TPGS | TPGS | vitamine E PEG-1000-succinate | alpha-tocopheryl polyethylene glycol succinate | (+)-alpha-tocopheryl polyethylene glycol 1000 succinate | tocopheryl poly(ethylene glycol) 1000 succinate | tocophersolan, (2R-(2R*(4R*,8R*)))-isomer | tocopherol poly(ethylene glycol) 2000 succinate | alpha-D-tocopherol poly(ethylene glycol) 2000 succinate | TPGS 2K |
|
| Chemical Information |
| Molecular Formula |
C35H58O6 |
| CAS Registry Number |
30999-06-5 |
| SMILES |
CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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|
