| Drug Name |
Tobramycin |
| Drug ID |
BADD_D02232 |
| Description |
Aminoglycosides, many of which are derived directly from _Streptomyces_ spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms.[A232294] Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics.[A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.[L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.[A232294, A232349, L32739, L32749]
Tobramycin was approved by the FDA in 1975 and is currently available in a variety of forms for administration by inhalation, injection, and external application to the eye (ophthalmic).[L32739, L32744, L32749] |
| Indications and Usage |
For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
J01GB01; S01AA12 |
| DrugBank ID |
DB00684
|
| KEGG ID |
D00063
|
| MeSH ID |
D014031
|
| PubChem ID |
36294
|
| TTD Drug ID |
D07BCT
|
| NDC Product Code |
47335-171; 68788-7252; 65162-914; 63187-973; 51927-0226; 68083-312; 49502-401; 0078-0630; 68071-2272; 51927-2375; 53002-9230; 60760-583; 36000-242; 17478-290; 61314-643; 61919-598; 70644-899; 55700-747; 0404-7196; 76420-092; 0078-0494; 0093-4085; 70518-1370; 45865-427; 68180-962; 20076-2006; 42513-0011; 81861-0030; 49502-346; 0065-0644; 51846-1012; 68083-241; 0078-0813; 68071-4537; 51552-1520; 24492-850; 67457-473; 72266-163; 24208-290; 11014-0233; 50090-3569; 67457-428; 0065-0643; 50090-0486; 59651-129; 57885-0002; 68083-254; 53002-9232; 68083-374; 67877-678; 71205-101; 53002-9231; 61919-642; 36000-244; 13985-604; 45865-119; 39822-0412; 63187-024; 70700-173; 49502-345; 11722-073; 72266-196; 68083-253; 17478-340; 0093-3750; 63187-902; 10122-820; 53002-9233; 70069-131 |
| Synonyms |
Tobramycin | Nebramycin Factor 6 | Tobramycin Sulfate | Sulfate, Tobramycin | Obracin | Tobracin | Brulamycin | Nebcin | Nebicin |
