Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tirofiban
Drug ID BADD_D02228
Description Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Indications and Usage For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
Marketing Status Prescription; Discontinued
ATC Code B01AC17
DrugBank ID DB00775
KEGG ID D08607
MeSH ID D000077466
PubChem ID 60947
TTD Drug ID D0BN9X
NDC Product Code 25208-002; 25208-001; 68083-145
Synonyms Tirofiban | N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine | Aggrastat | Agrastat | MK 383 | MK-383 | L 700462 | L-700462 | L-700,462 | L 700,462 | L700,462 | Tirofiban Hydrochloride | Tirofiban Hydrochloride Monohydrate
Chemical Information
Molecular Formula C22H36N2O5S
CAS Registry Number 144494-65-5
SMILES CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresIntegrin alpha-IIbP08514Not Available10195947; 11447076; 11151063; 11425767
Surgical and medical proceduresIntegrin beta-3P05106T2645710195947; 11447076; 11151063; 11425767
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Activated partial thromboplastin time prolonged13.01.02.0010.000556%
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000371%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Arterial thrombosis24.01.01.0020.000371%Not Available
Bradycardia02.03.02.002--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000726%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chills15.05.03.016; 08.01.09.001--
Death08.04.01.0010.001355%
Dissecting coronary artery aneurysm24.02.02.002; 02.02.01.009--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Extradural haematoma24.07.04.002; 17.08.05.001; 12.01.10.002--Not Available
Gingival bleeding24.07.02.010; 07.09.07.0010.000556%Not Available
Haematocrit decreased13.01.05.001--Not Available
Haematoma24.07.01.0010.000556%
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.000556%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.005371%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Myocardial infarction24.04.04.009; 02.02.02.0070.001258%
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain in extremity15.03.04.010--
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Pericardial haemorrhage24.07.01.013; 02.06.01.003--Not Available
Platelet count decreased13.01.04.001--
Presyncope02.01.02.007; 24.06.02.010; 17.02.05.009--
Pulmonary alveolar haemorrhage24.07.01.015; 22.01.02.0050.000371%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.003--
Pyrexia08.05.02.003--
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