Pharmaceutical Information |
Drug Name |
Tipranavir |
Drug ID |
BADD_D02226 |
Description |
Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV. |
Indications and Usage |
For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors. |
Marketing Status |
Prescription |
ATC Code |
J05AE09 |
DrugBank ID |
DB00932
|
KEGG ID |
D08605
|
MeSH ID |
C107201
|
PubChem ID |
54682461
|
TTD Drug ID |
D0EV6T
|
NDC Product Code |
11014-0046; 12714-901; 0597-0003; 0597-0002 |
Synonyms |
tipranavir | tipranavir, (R-(R*,R*))-isomer | 3'-((1R)-1-((6R)-5,6-dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2h-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide | Aptivus | tipranavir, (S-(R*,R*))-isomer | tipranavir, (S-(R*,S*))-isomer | tipranavir glucuronide | (2R)-3,6-Dihydro-6-oxo-2-(2-phenylethyl)-2-propyl-5-((1R)-1-(3-(((5-(trifluoromethyl)-2-pyridinyl)sulfonyl)amino)phenyl)propyl)-2H-pyran-4-yl beta-D-glucopyranosiduronic acid | tipranavir, (R-(R*,S*))-isomer | tipranavir C-14 | C14-tipranavir | 14C-tipranavir | tipranavir disodium | PNU-140690E | tipranavir sodium | PNU 140690 | PNU-140690 |
|
Chemical Information |
Molecular Formula |
C31H33F3N2O5S |
CAS Registry Number |
174484-41-4 |
SMILES |
CCCC1(CC(=C(C(=O)O1)C(CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)O)CCC4=CC=
CC=C4 |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
|
ADRs Induced by Drug |
ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
Lipohypertrophy | 23.07.01.005; 14.08.04.009 | - | - | | Hyperamylasaemia | 14.11.01.003 | - | - | Not Available | Nail atrophy | 23.02.05.010 | - | - | Not Available |
|
|
|