Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Timolol maleate
Drug ID BADD_D02220
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
Marketing Status Prescription; Discontinued
ATC Code C07AA06; S01ED01
DrugBank ID DB00373
KEGG ID D00603
MeSH ID D013999
PubChem ID 5281056
TTD Drug ID D05UVD
NDC Product Code 54871-1088; 70447-0002; 64980-514; 0378-0221; 24208-816; 51014-7510; 0378-0055; 50090-0558; 67877-229; 60758-801; 55545-0440; 45865-121; 0378-0715; 24208-813; 60758-802; 24208-812; 49452-7813; 24208-499; 50090-3441; 61314-226; 61314-225; 17478-289; 50090-5091; 73152-030; 61314-224; 24208-814; 51927-2003; 50090-5769; 63629-7167; 69918-602; 24208-818; 50383-021; 73152-031; 13811-618; 24208-004; 64980-513; 17478-288; 11722-076; 38779-0366; 68682-813; 0187-1498; 61314-227; 69918-601; 24208-496; 17337-0543; 64330-014; 24208-819; 52423-0913; 82260-496; 46014-1059; 60505-1005; 73152-029; 68682-045; 24208-498; 0187-1496; 68682-812
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C17H28N4O7S
CAS Registry Number 60469-65-0
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Blood potassium13.11.01.032--Not Available
Blood triglycerides13.12.03.004--Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid13.02.04.003--Not Available
Bradycardia02.03.02.002--Not Available
Bronchial obstruction22.03.01.013--
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Catatonia19.11.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention17.03.03.001; 19.21.02.002--
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