Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticlopidine hydrochloride
Drug ID BADD_D02216
Description Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code B01AC05
DrugBank ID DB00208
KEGG ID D01028
MeSH ID D013988
PubChem ID 65335
TTD Drug ID D05LBU
NDC Product Code 55486-1565; 49706-0331; 12660-0501
Synonyms Ticlopidine | Ticlopidine Hydrochloride | Hydrochloride, Ticlopidine | Ticlodix | Ticlodone | 53-32C | 53 32C | 5332C | Ticlid
Chemical Information
Molecular Formula C14H15Cl2NS
CAS Registry Number 53885-35-1
SMILES C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Agranulocytosis01.02.03.001--Not Available
Alveolitis allergic10.01.03.008; 22.01.01.002--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Bleeding time prolonged13.01.02.002--Not Available
Colitis07.08.01.001--
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dyspepsia07.01.02.001--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eosinophilia01.02.04.001--
Epistaxis22.04.03.001; 24.07.01.005--
Erythema multiforme23.03.01.003; 10.01.03.015--
Flatulence07.01.04.002--
Gastrointestinal pain07.01.05.005--
Haematuria24.07.01.047; 20.02.01.006--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hyponatraemia14.05.04.002--
Jaundice cholestatic09.01.01.005--Not Available
Jaundice hepatocellular09.01.01.006--Not Available
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