Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticlopidine
Drug ID BADD_D02215
Description Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code B01AC05
DrugBank ID DB00208
KEGG ID D08594
MeSH ID D013988
PubChem ID 5472
TTD Drug ID D05LBU
NDC Product Code Not Available
Synonyms Ticlopidine | Ticlopidine Hydrochloride | Hydrochloride, Ticlopidine | Ticlodix | Ticlodone | 53-32C | 53 32C | 5332C | Ticlid
Chemical Information
Molecular Formula C14H14ClNS
CAS Registry Number 55142-85-3
SMILES C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Alveolitis allergic22.01.01.002; 10.01.03.008--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Blood cholesterol increased13.12.01.002--
Body temperature increased13.15.01.001--Not Available
Colitis07.08.01.001--
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.002--Not Available
Eosinophilia01.02.04.001--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Flatulence07.01.04.002--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
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